UC San Diego
Quantitative Biology Ph.D Specialization

Discover Quantitative Biology (qBio) at UC San Diego

qBio is the power of math-based reasoning and advanced instrumentation from physics and engineering harnessed to discover fundamental principles of living systems.

To make biology quantitative and predictive, it is necessary to draw upon a multitude of approaches from the physical sciences and engineering. These include theoretical concepts developed from studies in statistical mechanics and nonlinear dynamics, and experimental methods such as microfluidics and advanced imaging. Therefore the goal of the qBio graduate program is to provide the students with a mastery of both the theoretical knowledge and experimental skills, and guide them to employ both approaches to address fundamental biological problems during their thesis research.

Discover Our Hacker Lab

Hacking a Revolution in Biology

Graduate students in new quantitative biology doctoral program learn to modify microscopes and other instruments to probe frontiers of their emerging discipline

Learn more about the qBio Hacker lab. -->


Scientists Determine How Birds Soar to Great Heights
Tue, Nov 15, 2016 1:55 pm     A+ | a-
Scientists Determine How Birds Soar to Great Heights
Soaring bald eagle. Photo: iStock © Kenneth Canning

Migratory birds often use warm, rising atmospheric currents to gain height with little energy expenditure when flying over long distances.

It’s a behavior known as thermal soaring that requires complex decision-making within the turbulent environment of a rising column of warm air from the sun baked surface of the earth. But exactly how birds navigate within this ever-changing environment to optimize their thermal soaring was unknown until a team of physicists and biologists at the University of California San Diego took an exacting computational look at the problem.

In this week’s online version of the journal Proceedings of the National Academy of Sciences,the scientists demonstrated with mathematical models how glider pilots might be able to soar more efficiently by adopting the learning strategies that birds use to navigate their way through thermals.

“Relatively little is known about the navigation strategies used by birds to cope with these challenging conditions, mainly because past computational research examined soaring in unrealistically simplified situations,” explained Massimo Vergassola, a professor of physics at UC San Diego.

To tackle the problem, he and his colleagues, including Terrence Sejnowski, a professor of neurobiology at the Salk Institute and UC San Diego, combined numerical simulations of atmospheric flow with “reinforcement learning algorithms”—equations originally developed to model the behavior and improved performance of animals learning a new task. Those algorithms were developed in a manner that trained a glider to navigate complex turbulent environments based on feedback on the glider’s soaring performance.

According to Sejnowski, the “reinforcement learning architecture” was the same as that used by Google’s DeepMind AlphaGo program, which made headlines in 2016 after beating the human professional Go player Lee Sedol.

When applying it to soaring performance, the researchers took into account the bank angle and the angle of attack of the glider’s wings as well as how the temperature variations within the thermal impacted vertical velocity.

“By sensing two environmental cues—vertical wind acceleration and torque—the glider is able to climb and stay within the thermal core, where the lift is typically the largest, resulting in improved soaring performance, even in the presence of strong turbulent fluctuations,” said Vergassola. “As turbulent levels rise, the glider can avoid losing height by adopting increasingly conservative, risk-averse flight strategies, such as continuing along the same path rather than turning.”

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By Kim McDonald